PHARMACEUTICAL ORGANIC CHEMISTRY-I LAB

PHARMACEUTICAL ORGANIC CHEMISTRY-I LAB
SYLLABUS 2009-10

B. Pharmacy I Year
P C
3 4

JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY
ANANTAPUR.

PHARMACEUTICAL ORGANIC CHEMISTRY-I LAB

Introduction to Equipment & Glassware, Recrystallization method, details of M.P, B.P and distillation

I. Preparation of organic compounds (each involving a specific organic reaction covered in theory)

1.N-Acetylation : Preparation of Acetanilide from Aniline
2. O-Acetylation : Preparation of Aspirin from Salicylic acid
3.Nuclear Bromination : Preparation of p-Bromoacetanilide from
Acetanilide
4.Hydrolysis : Preparation of p-Bromoaniline from
p-Bromoacetanilide
5.Nuclear Nitration : Preparation of m-Dinitrobenzene from
Nitrobenzene
6.Reduction : Preparation of m-nitro aniline from
m-dinitro benzene.

7.Oxidation :Preparation of Benzoic acid from
Benzyl chloride

8.Esterification :Preparation of n-Butylacetate from
n-Butylalcohol
9.Etherification :Preparation of -Naphthyl methyl ether
from -Naphthol
10.-Halogenation : Preparation of Iodoform from Oxidation of of Acetone / Ethanol
11.Extensive Nuclear Substitution :Preparation of tribromophenol

12Bromination :Tribromoaniline from Phenol or Aniline
13Addition / elimination: :Preparation of phenyl hydrazone or oxime from
Benzaldehyde

II. Identification of organic compounds belonging to following classes by systematic qualitative organic analysis including preparation of derivatives.
1. Phenols
2. Amides
3. Carbohydrates
4. Amines
5. Carboxylic acids
6. Aldehydes and Ketones
7. Alcohols
8. Anilides and nitrocompounds
9. Esters