GPAT - PGCET - GATE Material related to - Pharmacology of Antiparkinsonian Drugs

GPAT - PGCET - GATE Material related to - Pharmacology of Antiparkinsonian Drugs
For Quick Reference

What is Antiparkinsonian ( or ) What are Antiparkinsonian Drugs Pharmacology ?

Antiparkinsonian :


- Chronic, progressive, degenerative disorder affecting the dopamine- producing centers


-  Inbalance of dopamine (inhibiting) and acetylcholine (excitatory)


-  Bradykinesia, Rigidity, Tremor, Postural Instability


-  Treatment geared toward slowing dopamine degradation and
    increasing dopamine production or replacement

Types :

 Neuroprotective Agents

  • MAO-B Inhibitor (Seligiline)

  • Vitamins E and C - experimental

 Dopaminergic Agents

    • Levadopa, Carbidopa (dopamine replacement)

    • Mirapex, ReQuip (dopamine agonists)

 Anticholinergic Agents :

  • Benztropine



Side / Adverse Effects of Antiparkinsonian Drugs :


  Neuroprotective Agents

• Hypotension, dysrhythmia, extrapyramidal effects, N/V, anorexia, Asthma

   Dopaminergic Agents

• Orthostatic Hypotension, psychotic episodes, Hemolytic anemia

   Anticholinergic

• Drowsiness, confusion, Urinary retention, Blurred vision, Mydriasis, Photophobia


Toxicity :


Abrupt discontinuation of Anticholinergic meds may result
on SLUDGE - May require Atropine

• S Salivation

• L Lacrimation

• U Urination

• D Diarrhea

• G Gastrointestinal motility

• E Emesis